Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials
Precise-world medical effectivity of financial SARS-CoV-2 quick antigen exams in suspected COVID-19: A scientific meta-analysis of accessible information as per November 20, 2020
Goals: Speedy antigen exams, or RATs, are a sort of lateral circulation chromatographic immunoassay which had been utilized to assist prognosis of SARS-CoV-2 an an infection. We carried out a scientific meta-analysis to match the real-world effectivity of commercially obtainable RATs.
Methods: We searched various databases and internet sites for manufacturer-independent potential medical effectivity analysis evaluating SARS-CoV-2 RATs and RT-PCR. Solely analysis on RATs that did not need a separate reader for final result retrieval and that reported information on viral load, victims’ symptom standing, sample variety, and PCR assay used had been included.
Outcomes: 19 analysis utilizing 11,109 samples with 2,509 RT-PCR-positives had been included. RAT sensitivity completely different between 28.9% (95% CI 16.4-44.3) and 98.3% (95% CI 91.1-99.7), probably dependent upon inhabitants traits, viral load, and symptom standing.
RAT specificity completely different between 92.4% (95% CI 87.4-95.9) and 100% (95% CI 99.7-100) with one outlier. The RATs by Roche Diagnostics/SD Biosensor and Abbott had the perfect pooled sensitivity (82.4% [95% CI 74.2-88.4] and 76.9% [95% CI 72.1-81.2], respectively). Sensitivity in high-viral-load samples (cycle threshold ≤25) confirmed heterogeneity among the many many completely completely different RATs.
Conclusion: The RATs supplied by Roche Diagnostics/SD Biosensor and Abbott current ample manufacturer-independent, real-world effectivity information to assist their use for detection of current SARS-CoV-2 an an infection, notably in high-viral-load populations.
Key phrases: COVID-19; SARS-CoV-2; immunoassay; lateral circulation; point-of-care testing; quick antigen examine.
Evaluation of Triage Checks When Present Test Functionality Is Constrained: Utility to Speedy Diagnostic Testing in COVID-19
Goals: A triage examine is used to seek out out which victims will endure an present or “reference” examine. This textual content explores the potential price of using triage exams sooner than reference exams when the aptitude of the reference examine is constrained.
Methods: We developed a simple model with inputs: prevalence, sensitivity, specificity, and reference examine functionality. We included a case analysis of quick diagnostic exams for SARS-CoV-2 antigens used as triage exams sooner than a reference polymerase chain response examine. Effectivity information had been obtained from an evaluation carried out by an academic coronary heart on 425 samples from testing services within the UK and Germany.
Outcomes: When reference examine functionality is constrained, the utilization of a triage examine leads to a relative progress of the inhabitants examined and circumstances acknowledged; every are bigger with a high-specificity triage examine.
When reference examine functionality is simply not constrained, the potential advantages of introducing a triage examine can be assessed using a typical cost-utility framework, balancing the utility of the low cost inside the number of reference exams required in direction of the disutility of missed circumstances associated to the utilization of a lower-sensitivity triage examine.
Inside the constrained case, the advantage of a triage testing approach by means of inhabitants lined and circumstances acknowledged is lowered as a result of the prevalence will improve. Inside the unconstrained case, the low cost in reference exams required is lowered and the number of circumstances missed improve as a result of the prevalence rises.
Conclusion: When the supply of the reference examine is constrained, exams added in a triage place don’t desire extreme ranges of accuracy to increase the number of circumstances acknowledged. This has implications in numerous sickness areas, along with COVID-19.
Twitter: Lower-accuracy #COVID19 exams can nonetheless be useful, based mostly on a model new article, “Evaluation of Triage Checks When Present Test Functionality Is Constrained: Utility to Speedy Diagnostic Testing in COVID-19,” co-authored by @janetbouttell & @NeilSHawkins @HEHTAGlasgow @MedDecMak There could also be loads emphasis on high-accuracy #COVID19 exams, nevertheless lower-accuracy exams have their place, based mostly on a model new analysis on triage exams when examine functionality is constrained, co-authored by @janetbouttell & @NeilSHawkins @HEHTAGlasgow @MedDecMak A model new analysis, co-authored by @janetbouttell & @NeilSHawkins @HEHTAGlasgow, has confirmed that when there’s restricted functionality of high-accuracy #COVID19 diagnostic exams, triage testing strategies can improve the inhabitants lined and the number of #COVID19 circumstances acknowledged.
Speedy COVID-19 antigenic exams: Usefulness of a modified approach for prognosis
Background: The current reliable actually useful examine for COVID-19 prognosis is RT-qPCR. Speedy antigen examine items could very properly be useful as they’re cheap, sooner with out the need of specialized laboratories to hold out the examine.
We report the performances of two quick immunochromatographic antigen testing items as compared with RT-qPCR for SARS-CoV-2 detection in medical samples.
Methods: We carried out a lateral-flow exams analysis on 401 nasopharyngeal swab samples from non-duplicated suspected COVID-19 matters. An equal amount of UTM-containing samples (dilution ratio = 1:15) had been added to producer’s extraction buffer decision (dilution ratio = 1:2) and analyzed on BioSpeedia COVID19Tempo-Antigen Test and on Abbott PanbioTM COVID-19 Ag Speedy Test, items. Qualitative outcomes had been as compared with these obtained by the RT-qPCR (Allplex™ SARS-CoV-2 Assay Seegene).
Outcomes: Based on our information, normal sensitivity for BioSpeedia and Panbio items had been estimated at 65.5 and 75.0 %, respectively.
The sensitivity was higher for cycle threshold values decrease than 25 reaching 90.4 and 96.eight for BioSpeedia and Panbio items, respectively. A super specificity of 100.0% was seen for every items.
Conclusion: BioSpeedia and Panbio, as quick antigen exams with fantastic sensitivity to detect extreme viral a whole lot, appeared to be reliable choices to RT-qPCR notably useful when molecular testing functionality is also saturated by overflow of samples.
Given the extreme specificity of items, a optimistic final result would not require affirmation by a molecular examine and would as a consequence of this truth allow a sooner administration of COVID-19-positive victims. This textual content is protected by copyright. All rights reserved.
 Goat TGFR ELISA Kit |
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| EGTT0062 | Abclonal | 96Tests | EUR 625.2 |
 Mouse TGFR ELISA Kit |
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| EMT0062 | Abclonal | 96Tests | EUR 625.2 |
 Sheep TGFR ELISA Kit |
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| EST0062 | Abclonal | 96Tests | EUR 625.2 |
 Rabbit TGFR ELISA Kit |
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| ERTT0062 | Abclonal | 96Tests | EUR 625.2 |
 Monkey TGFR ELISA Kit |
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| EMKT0062 | Abclonal | 96Tests | EUR 625.2 |
 Bovine TGFR ELISA Kit |
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| EBT0062 | Abclonal | 96Tests | EUR 625.2 |
 Canine TGFR ELISA Kit |
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| ECT0062 | Abclonal | 96Tests | EUR 625.2 |
 Porcine TGFR ELISA Kit |
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| EPT0062 | Abclonal | 96Tests | EUR 625.2 |
 Chicken TGFR ELISA Kit |
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| ECKT0062 | Abclonal | 96Tests | EUR 625.2 |
 Anserini TGFR ELISA Kit |
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| EAT0062 | Abclonal | 96Tests | EUR 625.2 |
 Guinea Pig TGFR ELISA Kit |
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| EGT0062 | Abclonal | 96Tests | EUR 625.2 |
 Recombinant Human ALK-1 Protein |
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| RP00978 | Abclonal | 5 μg | EUR 163.2 |
Recombinant Human ALK-1 Protein |
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| VAng-2860Lsx-10g | Creative Biolabs | 10 µg | EUR 736.8 |
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Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein |
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| VAng-2860Lsx-1mg | Creative Biolabs | 1 mg | EUR 16605.6 |
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Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
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) Goat anti Human IgG (Alk Phos) |
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| 43C-CB0963 | Fitzgerald | 1 mg | EUR 433.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43C-CB0978 | Fitzgerald | 1 mg | EUR 483.6 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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) Goat anti Human IgM (Alk Phos) |
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| 43C-CB0999 | Fitzgerald | 1 mg | EUR 456 |
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Description: Goat anti Human IgM secondary antibody (Alk Phos) |
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) Goat anti Human IgG (Alk Phos) |
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| 43R-1169 | Fitzgerald | 1 mg | EUR 223.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1175 | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1192 | Fitzgerald | 1 mg | EUR 315.6 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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) Goat anti Human IgG (Alk Phos) |
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| 43R-1204 | Fitzgerald | 500 ug | EUR 355.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-IG012alk | Fitzgerald | 1 ml | EUR 658.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-IG165ALK | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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) Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0949 | Fitzgerald | 1 mg | EUR 526.8 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0956 | Fitzgerald | 1 mg | EUR 450 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0970 | Fitzgerald | 1 mg | EUR 450 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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) Rabbit anti Human IgM (Alk Phos) |
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| 43C-CB9106 | Fitzgerald | 1 mg | EUR 522 |
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Description: Rabbit anti Human IgM secondary antibody (Alk Phos) |
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) Rabbit anti Human IgA (Alk Phos) |
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| 43C-CB9120 | Fitzgerald | 1 mg | EUR 475.2 |
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Description: Rabbit anti Human IgA secondary antibody (Alk Phos) |
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 ALK-1 Polyclonal Antibody |
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| 41591-100ul | SAB | 100ul | EUR 302.4 |
ALK-1 Polyclonal Antibody |
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| 41591-50ul | SAB | 50ul | EUR 224.4 |
ALK-1 Polyclonal Antibody |
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| ABP52913-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP52913-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP52913-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ES3912-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES3912-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES8031-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES8031-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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 Anti-ALK-1 antibody |
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| STJ96547 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to ALK-1. |
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Anti-ALK-1 antibody |
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| STJ91563 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to ALK-1. |
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 Nori® Human ALK-1 ELISA Kit |
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| GR111542 | Genorise Scientific | 96-well | EUR 461 |
) Human ALK and LTK ligand 1 (ALKAL1) |
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| 1-CSB-EP757795HU | Cusabio |
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Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli |
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 ELISA kit for Human ALK-1/ACVRL1 |
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| EK5715 | SAB | 96 tests | EUR 663.6 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human ALK-1/ACVRL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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 ALK-IN-1 |
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| HY-13464 | MedChemExpress | 100mg | EUR 472.8 |
 Human ALK-1/ACVRL1 PicoKine ELISA Kit |
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| EK1518 | BosterBio | 96 wells | EUR 510 |
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Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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) Goat anti Human IgG Fc (Alk Phos) |
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| 43-I24 | Fitzgerald | 100 ug | EUR 198 |
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Description: Goat anti Human IgG Fc secondary antibody (Alk Phos) |
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 ALK inhibitor 1 |
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| HY-15357 | MedChemExpress | 50mg | EUR 1712.4 |
) Goat anti Human Kappa Chain (Alk Phos) |
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| 43C-CB9127 | Fitzgerald | 1 mg | EUR 500.4 |
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Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos) |
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) Goat anti Human kappa chain (Alk Phos) |
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| 43R-1257 | Fitzgerald | 500 ug | EUR 482.4 |
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Description: Goat anti Human kappa chain secondary antibody (Alk Phos) |
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) Goat anti Human Lambda Chain (Alk Phos) |
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| 43C-CB9134 | Fitzgerald | 1 mg | EUR 500.4 |
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Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos) |
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 ALK-1 Polyclonal Conjugated Antibody |
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| C41591 | SAB | 100ul | EUR 476.4 |
 (Alk Phos)) Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0921 | Fitzgerald | 1 mg | EUR 205.2 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0928 | Fitzgerald | 1 mg | EUR 417.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0935 | Fitzgerald | 1 mg | EUR 543.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1145 | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1157 | Fitzgerald | 500 ug | EUR 268.8 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1163 | Fitzgerald | 500 ug | EUR 315.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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) Recombinant Human ALK-1 Protein (aa 22-503) |
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| VAng-2854Lsx-100g | Creative Biolabs | 100 µg | EUR 8440.8 |
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Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-503) |
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| VAng-2854Lsx-50g | Creative Biolabs | 50 µg | EUR 5454 |
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Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
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) Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-1mg | Creative Biolabs | 1 mg | EUR 3393.6 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-200g | Creative Biolabs | 200 µg | EUR 2205.6 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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 ALK-1 Recombinant Protein |
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| 92-565 | ProSci | 0.05 mg | EUR 374.1 |
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Description: Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair. |
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 Anti-ALK Antibody Clone ALK/1503, Unconjugated-20ug |
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| 238-MSM3-P0 | EnQuireBio | 20ug | EUR 279.6 |
 (Alk Phos)) Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0914 | Fitzgerald | 1 mg | EUR 478.8 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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) Goat anti Human IgG + IgA + IgM (Alk Phos) |
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| 43R-1245 | Fitzgerald | 1 mg | EUR 205.2 |
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Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
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Goat anti Human IgG + IgA + IgM (Alk Phos) |
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| 43R-1251 | Fitzgerald | 500 ug | EUR 268.8 |
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Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43R-1269 | Fitzgerald | 1 mg | EUR 295.2 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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 (Alk Phos)) Donkey anti Human IgG (H + L) (Alk Phos) |
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| 43R-ID001alk | Fitzgerald | 500 ul | EUR 390 |
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Description: Donkey anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43-I23 | Fitzgerald | 1 mg | EUR 435.6 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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 (Target 1)) ALK sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K0074502 | ABM | 1.0 ug DNA | EUR 184.8 |
 Anti-ALK Antibody Clone ALK/1503, Unconjugated-100ug |
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| 238-MSM3-P1 | EnQuireBio | 100ug | EUR 513.6 |
 (Alk Phos)) Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1227 | Fitzgerald | 1 mg | EUR 274.8 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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 (Alk Phos)) Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1233 | Fitzgerald | 500 ug | EUR 456 |
|
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1239 | Fitzgerald | 500 ug | EUR 456 |
|
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43-I34 | Fitzgerald | 1 mg | EUR 232.8 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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 (Alk Phos)) Goat anti Human IgA (alpha chain) (Alk Phos) |
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| 43R-1119 | Fitzgerald | 500 ug | EUR 355.2 |
|
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
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 (Alk Phos)) Goat anti Human IgG (gamma chain) (Alk Phos) |
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| 43R-1659 | Fitzgerald | 1 mg | EUR 301.2 |
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Description: Goat anti Human IgG (gamma chain) secondary antibody (Alkaline Phosphatase) |
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Goat anti Human IgA (alpha chain) (Alk Phos) |
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| 43-I10 | Fitzgerald | 1 mg | EUR 355.2 |
|
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
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 (Alk Phos)) Goat anti Human IgE (epsilon chain) (Alk Phos) |
|||
| 43R-1129 | Fitzgerald | 1 mg | EUR 456 |
|
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
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Goat anti Human IgE (epsilon chain) (Alk Phos) |
|||
| 43R-1134 | Fitzgerald | 500 ug | EUR 456 |
|
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
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 Goat Anti Human Ige Polyclonal Antibody,Alk. Phos. |
|||
| CPBT-65486GH | Creative Diagnostics | 0.5 mg | EUR 696 |
 [Fc]) Recombinant Human ALK-1 Protein (aa 22-118) [Fc] |
|||
| VAng-2859Lsx-50g | Creative Biolabs | 50 µg | EUR 621.6 |
|
Description: Recombinant Human ALK-1 was expressed in HEK 293 cells. (Uniprot ID: P37023) |
|||
 ALK 1 Recombinant Protein |
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| 96-022 | ProSci | 0.1 mg | EUR 619.8 |
|
Description: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells. |
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